Abstract: The author summarized the characteristics of Zhiluo Formation structure, sedimentary facies, oxidation zone and gamma anomaly distribution of the target layer in Jianzhuang area, established the "three-transition" uranium ore positioning model, and directed the uranium ore prospecting work in Jianzhuang area. It is pointed out that the scale of the "three-transition" composite area is the main factor affecting the continuity of industrial ore body, which has a good reference significance for uranium ore prospecting and comprehensive research.