Abstract: Sanyu area is located in the Yawan−Daqiao gold−antimony ore belt of Gansu Province, which belongs to the national integrated exploration, and has the metallogenic conditions and prospecting potential of gold, antimony, copper and other polymetals. In order to further improve the geological prospecting work, 1∶25000 soil geochemical survey was carried out in the research area. Based on the original data of Au, Ag, Cu, Pb, Zn, Ni, Sb, Bi and Hg elements, fractal characteristics, coefficient of variation, coefficient of concentration and other methods, The basic data of 9 elements were statistically analyzed, and the spatial enrichment status and distribution trend of elements were analyzed. The results showed that Pb, Zn, Sb and Au had certain prospecting indexes, SPSS 25 was used for clustering and factor analysis of 9 elements, and three combination elements were divided into F1 (Ag−Pb−Zn−Sb), F2 (Au−Cu−Ni−Bi) and F3 (Hg). The lower limit of element combination anomaly was obtained by contrast anomaly method, and according to software Sufer. The factor score anomaly map of 13 combination elements was made, and a total of 4 prospecting prospects were delineated, which provided a basis for further geological prospecting and reduction of prospective areas.