Abstract: In order to deepen the study on the metallogenic regularity of Ta–Nb rare element metallogenic belt and fully exploit the ore–prospecting favorable information contained in the aerial geophysical data in Alto Ligonha, Mozambique, the high–precision aeromagnetic and aeroradiometric survey grid data are collected in northern Mozambique and converted to enhance the extraction of weak metallogenic information. Based on the achievement recognition, the comprehensive inference and interpretation are carried out about the geological structure in the area. The distribution characteristics are analyzed and summarized of the aeromagnetic and aeroradiometric anomalies, and their spatial correspondences with pegmatite Ta–Nb ore in the area is discussed. A comparative study is carried out to find out the scope of Namama overthrust nappe belt, the main ore–controlling structure in the area and the distribution characteristics of internal fault structures. Combined with the comprehensive anomaly characteristics of the large Ta niobium deposit in the area, the analogy prospecting prediction was made for the whole area, and five Ta–Nb deposit prospects were delineated. It is believed that the northeastward extension of the metallogenic belt is faulted by F2 fault, and the southwestward fault distance is more than 20 km, which leads to the overall NW transfer of the favorable ore–forming area, and it is of great prospecting significance to pursue the anomaly.