Abstract: Hongliugou basic-ultrabasic rock mass is a copper–nickel mineralized rock mass newly discovered and determined during the author's 1∶50 000 mineral geological survey. It is located in the Beishan Rift zone on the northern margin of Tarim Plate, sandwiched Dashantou–Gangliuxin and Fangshankou–Miaomiaojing– Shuangyingshan fault zone, and is about 30 km to the northwest from Heishan large copper–nickel deposit. Under the premise of fully and systematically studying the geological background, comprehensive prospecting techniques such as geological, physical, chemical and remote prospecting are used to sweep the blank area with 1∶50000 drainage sediment and magnetic survey to delineate anomalies, and then large–scale geological survey and exciting elevator profile survey are carried out to further delineate some favorable ore–forming areas in the metallogenic area. The channel exploration and drilling engineering verification are carried out in an optimal manner, and the Cu–Ni ore spots No. Ⅲ and IV in Hongliugou are newly discovered, and better prospecting results have been obtained, which indicates that the comprehensive application of physicochemical prospecting method is feasible and effective, and has reference significance for further guiding the Cu–Ni prospecting work in this area and the region.