Abstract: GASH Au ore concentration area belongs to Bisha gold metallogenic belt in West Eritrea, with a good regional metallogenic setting. The geochemistry of stream sediment mapping at scale of 1∶100,000 indicate: Au, Hg, As, W, Bi are characteristic of strong-differentiated distribution, Au, As, Sb, W are characteristic of strong-rich distribution, showing a good prospecting for Au exploration. Through the correlation analysis, F5 factor (Au-Hg association) is confined to guide the Au exploration, F2 factor (Ag-Bi-Mo-W association) and F3 factor (As-Sb-Pb association) which are confined to guide the distribution of fault structures, F1 and F4 factor are confined to guide the distribution of basic and ultrabasic geological unit. with the anomaly information extract from F5 factor combined with the geological characteristic, 8 anomaly area with good Au metallogenic prospecting were determined, base on the characteristic of F2, F3, F5 factors, which are useful in indicating the metallogenic hydrothermal activity, 12 regional fault with NE, N-NE attitude were deduced. All the information extracted are useful geochemical evidence to the following gold exploration and the work deployment.