Abstract: In order to test the effectiveness of fluorite mineralization prospecting, we conducted geological survey, 1∶50 000 stream sediment survey, 1∶10000 soil geochemical profile, 1∶10000 high-precision magnetic survey, 1∶10 000 high-density resistivity profile and 1∶10000 resistivity profile in the Daxigou hydrothermal fissure filling fluorite deposit of Inner Mongolia. The results show that the 1∶50000 stream sediment survey can reduce the target area of prospecting. The geophysical exploration combination of high-precision magnetic survey, high-density resistivity and apparent resistivity profile can effectively detect the spatial extension and scale of surface ore-controlling faults. In addition, the high F anomalies in the soil geochemical profile can effectively identify the mineralization potential of the fault structure. By applying the combined geophysical and geochemical exploration techniques to the periphery of the Daxigou deposit, it is suggested that the ore-controlling structure extends to the northwest of more than 1000 m to the north of Huajianggou Village and two mineralized outcrops were found on the surface. On the basis of the surface trough exploration, it is revealed that the shallow surface ore body reached the industrial scale, which provided guidance for deep exploration in the periphyry. Furthermore, the here untilized exploration methods can provide some reference for prospecting of regional hydrothermal fissure filling fluorite deposits.