Abstract: Magmatic Ni-Cu sulfide are the main type of deposits in northwest China. Gansu Provincial Bureau of Geology and Mineral Exploration & Development has made some progress in the prospecting and exploration of Ni-Cu sulfide deposits in Beishan, Altun mountain, Qilian mountain and other areas in recent years, and its exploration and research achievements have been highly concerned by the industry. This paper systematically summarizes the new progress in the research of important Ni-Cu sulfide deposits in Gansu Province and the new breakthroughs in the prospecting of copper-nickel sulfide deposits such as Hongchuan and Da'aobaogou. The spatial and temporal distribution of mafic-ultramafic rock bodies (groups) in Gansu Province, the metallogenic geological conditions of magmatic Ni-Cu sulfide deposits, the main types of deposits and the characteristics of typical magmatic copper-nickel sulfide deposits are systematically sorted out and summarized. It analyzes the prospecting potential of magmatic copper-nickel sulfide deposits in Gansu Province and predicts prospective areas and important mineralized belts for prospecting. The prospecting direction is proposed, which provides important theoretical guidance for prospecting practice and theoretical research.