Abstract: By adopting the drilling technology of six-wheel drive vehicle pneumatic positive circulation DTH hammer + alloy scraper, a set of 1:50,000 geochemical exploration method has been proposed for the shallow overburden area with the thickness of cap layer less than 100m and the depth of groundwater more than 100m. This method includes sampling size, horizon, grid and sample collection. In this paper, the covered area of ore-prospecting potential surrounded the Yuhai deposit has been chosen to carry out the validation work. The results show that the delineated abnormal in covered area not only well reflects the known concealed ore deposit, but also has new prospecting breakthrough in the periphery covered area of the Yuhai deposit based on the anomaly verification work, where 5 new copper ore-bodies has been delineated and the scale of the Yuhai deposit expands. Therefore, the 1:50,000 vehicle-mounted shallow drilling geochemical exploration method and technology combination proposed in this study are effective in prospecting in the overburden area with intrusive rock as host rock mass in Yuhai area, east Tianshan Mountains, Xinjiang.