Abstract: Helium, an important rare strategic resource, has been widely used in the national defense industry and high-tech field. However, the helium supply in China heavily depends on imports, and the resource security situation is extremely severe. Previous investigations show that water-soluble helium resources are widely distributed and helium-rich gas reservoirs are locally enriched in the Weihe basin, and helium-rich gas is found in geothermal Wells in the northern part of Huazhou in the southern edge of Gushi depression. However, due to the low level of geophysical exploration in this area, it is difficult to reveal the helium accumulation rules and favorable exploration targets. In order to find out the geological conditions and enrichment mode of helium gas in Huazhou area and select favorable exploration targets. In recent years, our team has established a preliminary model of helium-rich natural gas accumulation and found multiple favorable trap targets in the study area, by geothermal well sampling test, helium source rock survey and analysis of carrier(gas) source rocks and reservoir caprock conditions. The comprehensive study shows that the eastern fault anticline in the north area of Huazhou has complete structure and weak structural reconstruction, and the most favorable conditions for helium rich gas accumulation. The discovery of this favorable exploration target points out the direction for the helium exploration in the Weihe basin, and is of great significance for the breakthrough of helium resource investigation in Weihe basin as soon as possible.