Abstract: Block D is situated in central Myanmar.It occupies an area of 12 384 km²,stretching from the north of Minbu Basin to the south of Chindwin Basin.Many oil fields are located to the south of Block D;among them is Letpando Oil Field,which lies right next to it.Further,many hand-dug wells and oil seeps exist in the area,which suggests the presence of a favorable oil and gas movement zone worthy of exploration.In order to study the next exploration efforts in the region,this paper examines closely the structural and sedimentary evolution of the area,with an emphasis on t he charact eristics of the oilgenerat edstrata,sedimentary facies of reservoirs and caprock,as w ll as the review of favorable oil and gas accumulation sites in the area.Middle-Late cretaceous Kabaw Formation and Early Eocene Laungshe Formation are the main oil -generating rock formatons;good reservoirs are sandst ones which include Miocene Let kat Formation,Eocene Pondaung Formation and Tilin Formation.Main caprockis developed from Miocene Nat ma Formation,Eocene Yaw Formation and Taby in Formation.Late Miocene to Early Pliocene formed from various local structural traps makes them potential oil and gas accumulation sites.The paper concludes that the region presents good oil and gas potential.