Abstract: On the basis of comprehensive analyses on geological setting and mineralization conditions in the eastern Kunlun metallogenic belt, this study systematically discusses metallogenic characteristics, mineralization processes and prospecting potential for skarn iron and poly metallic deposit, hydrothermal superimposed Sedex type Co-Au deposit, massive sulfide Cu-Co deposit and orogenic Au deposit with the examples of Kendekeke, Tuolugou, Duleng gou and Dachang deposits, respectively.Eight metallo genic prospective regions and thirteen prospecting targets have been determined by a regional metallogenic model, spatial distribution of different ore deposits and anomalies in the eastern Kunlun area.Also, an order of increasing metallogenic potential for mineralization zones in the area has been infer red as follows: central Kunlun area, Northern Kunlun area, Aneymaqen-northern Bayankala area, southern Kunlun area.