Abstract: On the base of comprehensively researching regional geological background, geochemical and geophysical characteristics in Feng-Tai multi-metal ore cluster region and combined with systematicly analyzing discovered mineral deposits here, there could be divided into three metallogenic series, including Devonian carbonate rock-hosted lead and zinc deposit metallogenic series, Devonian sedimentary reformation typed copper deposit metallogenic series, and Mesozoic orogenesis-related gold deposit metallogenic seried. It is concluded that Changgou-Donggou,Qiliping in Fengzhou and Weiziping-Donggou-Jianzigou region are very important for exploration in the nearfuture,and point clear prospecting direction for Changgou-Donggou,Tiziya-Sanjiaoya region. It is considered that discovered lead and zinc zone in Changgou-Donggou located in the same secondary hydrothermal sedimentary ba sin with Baguamiaogold deposit,which range coincide with that of He-2 anomaly,where hase good metallogen ic condition. South limb(overturned limb)and plunging end of Changgou anticline and Changgou-Baguamiao segment of Donggou anticline are animportan texploration target for lead,zinc and gold. These have important significance to guide exploration work in Feng-Tairegion.