Abstract: Talas-Kalatawu block is composed of Malakaluoyi terrane, Guokejiaote terrane and Wuzunahama'te terrane. The southern boundary of Talas-Kalatawu block is Taras-Fergana dextral strike-slip fault, and adjacent to Mid-Tianshan; the northern boundary is Suzaq-Yiqigelietawu-Alamu Zoe fault, and adjacent to North Tianshan. The three tectonic units varies from one another due to their sedimentary formation in different geological periods. According to the mineral-bearing formation and distribution of ore deposits and spots, the Block can be divided to four polymetallic mineralization belts. Long-term tectonic evolution and magmatic activity lead to the mineralization stacking in this field, however, the metallization is mainly formed by collision and extrusion magmatism in the late period of Caledonian orogeny.