Abstract: The Meizipu gold deposit in Ankang of Shaanxi province is located in the southern margin of Niushandi anticline, Caledonian North-Daba mountain fold belt, Qinling fold belt. The geochemical anomalies are re-delineated through soil regular network geochemical measurements. Results indicate that the anomalies of Au, Ag, Cu, Pb, As, Sb, Bi are obvious, and there are good correlations among Au, Ag and Pb, as well as As, Sb and Bi. Spatial distribution characteristics analysis of anomaly elements reflects that the ore-forming fluid or hydrothermal fluids migrated from southeast to northwest. The validation and analysis of key anomalies confirm that the combination of anomaly, mica-quartz schist and east-north schistosity structure is the indicator for deposit of gold mineralization enrichment area. In addition, geological structure and magmatic activity are ore-controlling factors. The clear combination of Au, As, Pb, Ag, Sb elements and the obvious accumulation center indicate that the anomaly is mineralized anomaly. The soil anomalies of Mt-2, Mt-4 and Mt-5 are the potential exploration region in this area. Characteristics of geochemical anomaly indicate that the denudation of east is stronger than west. Therefore, it can be speculated that concealed ore body of gold may exist in western area, and there is a great prospecting potential.