Abstract: From 1999 to the end of 2013, the project of creating 1:50000 regional geological map databases in northwest of China has completed 801 regional geological map spatial databases, metadatabases and relative documents, meanwhile, the work schedule map of building the databases has also been compiled. Through the accumulation of data, primary achievements have been made in the construction of a comprehensive large scale database in the northwest, and the 1:50000 regional geological survey data in the 5 provinces (district) of northwest China has been repaired. In the process of creating 1:50000 regional geological map spatial database, unified standard, reasonable technology route and reliable data quality monitoring methods were adopted to form a perfect quality control system for the created spatial database to ensure the quality of data, from the perspectives of mathematical foundation, spatial accuracy, topological consistency, and validity, etc. The informative database is object-oriented, and the data model is in line with the geological reality, which would form a series of products to meet the demand of the government and social benefit. Currently, it has been widely applied in the geological investigation, mineral resources potential evaluation, ecological environment evaluation and so on.