Abstract: The west of Henan province is an important gold polymetallic mineralization belt of China. The region has favorable ore-forming geological conditions and various types of gold polymetallic deposit. According to the analysis of geological characteristics and ore-forming geological conditions in this area, gold polymetallic deposits in the west of Henan province are controlled by multiple factors, mainly including strata, structures and magmatic rocks, among which structures are the dominant factors. On this basis, gold deposits inside researching area can be divided into altered fracture zone type, altered rock zone type, porphyry type, explosion breccia type. A typical ore deposit is selected from each type for analysis. According to the geologic characteristics of the gold deposits and five types of structural ore-control, this paper discussed the influence of detachment-metamorphic core complexes on structural ore-control and metallogenic regularity of the gold deposit mineralization. According to the mineralization regulations of gold deposits in researching area, eight indicators are proposed to select prospecting targets. Then, seven favorable prospecting targets are optimally selected.