Abstract: Identified by regional geology, geophysics and geochemistry, the study area located in Derbugan ore-forming belt is a favorable prospecting area for silver, lead and zinc poly-metallic deposit. Seriously covered quaternary system in the research area has caused great difficulties for geological and geochemical prospecting. Referring to the research and application of integrated geophysical methods, and combined with periodical geological and geochemical achievement, this article focused on ore exploration in Bogdewula concealed poly-metallic deposit, established a set of effective comprehensive prospecting model for hydrothermal concealed poly-metallic ore in this area, and summarized its model of geology-geophysics-geochemistry for ore prospecting with similar ore-forming conditions.