Abstract: According to metallogenic geological conditions and characteristics of Tongling area, and results of previous studies, deep mineralization and its process were discussed in this paper. Structural analysis shows that the Tongling area covers more than one deformation system with multiple stages. The deformation is dominant by fold and fault, and the deformation properties of strata below Silurian may have already changed; magmatic process showsthat ore-bearing rock are mainly syntectic granitoid;magma tite has obvious mineralization-exclusive characteristics. Copper-gold related rocks are mainly high-K calc-alkaline rocks, while iron-bearing and sulfur-bearing volcanic intrusionsare basically kohalaite rock series. Spatial distribution of magmatic rocks is mainly controlled by tectonic structure; magmatic hydrothermal migration in deep percolation is of middle scale, intruding upward in shallow as dykes. There is certain coupling relationship between ore-forming rock and surrounding rock. The ore mineralization takes place in Yanshanian. The summary of deposit distribution, types and mineralization law, combined with the mineralization prediction theory, the mineralization area, type and location were predicted.The study can provide reference forthe deep exploration in the Tongling area.