Abstract: Geological tectonic evolution is complicated in the north of Xinjiang and its magmatism and mineralization was disequilibrium among multi-stage evolutions. The period of Permian was high outbreak stage on large-scale magmatism and mineralization. This study focused on mafic-ultramafic intrusions and magmatic Ni-Cu sulfide deposits, and researched metallogenic background and geological process of deep magma activation through geological distribution characteristics of mafic-ultramafic intrusions, magma origin, magma evolution and mineralization characteristics of ore-bearing intrusions. By in-depth analysis of typical deposit, controlling factors that restricted prospecting were found out, geological characteristics and mineralization features of tectonic system coexistence of plate and mantle plume were systematically expounded. There were 5 mafic-ultramafic intrusion belts in north Xinjiang, and east Tianshan, Beishan and Kalatongke belts formed many magmatic Ni-Cu sulfide deposits related to mafic-ultramafic intrusions and large igneous province in time. The melt mantle material from the deep of Tarim craton upwells along the margin of rigid Tarim craton, and exchanges with supracrustal material. The deep mantle material strengthened constantly with sustainable weakened subduction, finally, different ore deposits were formed respectively because of deep mantle material content. Periphery or orogenic belts circling Tarim large igneous province is important direction for ore-formation theory study and prospecting of magmatic Ni-Cu sulfide deposits.