Abstract: The Hongluoshan-Wuzhishan region is important molybdenum, lead and zinc polymetallic metallogenic belt in west Liaoning. Results of previous studies show that the mineralization in this area has a close genetic relationship with widespread granitic rocks. Based on field investigation and indoor testing analysis methods, the origin, geochemical characteristics and its geological significance of these granites have been studied in this paper. The result show that these granites belong to K-feldspar granite andmonzonitic granite. Their w (SiO₂) content are 72.86%~76.56%, A/CNK ratios are 1.39~1.73, Alk values are 7.07~9.09, and the rock chemical parameters indicate that these granites are strongly peraluminous calc-alkaline rocks. Their Rb/Sr ratios are 0.63~2.31, with an average of 1.17, reflecting a higher degree of rock crystal fractionation. According to the results of Rb-Hf-Ta, Rb-Y+Nb and Rb-Yb+Ta diagrams, it's thought that these granites belongs to volcanic arc type, with genetic type of I (syntexis) type, having higher melting temperature. The diagenetic processes of these granites are related to the underplating of mantle-derived magma. The hot mantle-derived magma not only provides the thermal mass for the partial melting of crust, but also occurs the mixing with the molten crustal magma. With the evolution of magmatic differentiation, some minerals and ore deposit(mineralization) combination have been formed, and then developing Pb-Zn-Ag, Pb-Zn-Mo and Mo-Pb-Zn-Cu metallogenic series.