Abstract: Based on the stream sediment survey at scale 1:50 000 in Elashan area, the geochemical characteristics of Pb-Zn-Cu elements in this region have been analyzed. After analyzing the distribution characteristics of ore-forming elements and carrying out the correlation and factor analysis, the results show that it hasa potential to prospect the Pb-Zn-Cu polymetallic deposit in this region. According to the abnormal characteristics and the geological conditions of mineralization, it has a great potential to prospect Pb-Zn-Cu polymetallic epithermal and skarn deposits associated with Devonianto Jurassic intermediate-felsic rocks under the geological setting of Proterozoic Dakendaban (rock) Group, Ordovician Tanjianshan Group and Dagangou Formation in Carboniferous Zhongwunongshan Group. And then, five metallogenic prospect areas have been defined, that is, Shaliuhe W-Cu-Pb-Zn polymetallic mineralization prospective area, Danahaigongka and NorthGalu Pb-Zn polymetallic mineralization prospective areas, ZhalongjiadangPb-Zn-Ag-Au polymetallic mineralization prospective area and Nihaerrugang Pb-Zn-Ag-Mo mineralization prospective area.