Abstract: In the arid and semi-arid alpine region of east Kunlun, Qinghai province, the abnormal flow length of stream sediments is short, 1:50 000 stream sediment survey cannot satisfy the need of the geological prospecting.The 1:25 000 geochemical survey in Qinghai Province is mainly based on the stream sediment survey and aided by soil surveying, and the multi-point combination sampling method has been used in this survey, which has good decomposition and reproducibility for the comprehensive anomalies of 1:50 000 stream sediment survey, causing the more obvious, higher intensity concentration center for 1:25 000 geochemical survey comprehensive anomalies and the more accurate location of abnormal source.In recent years, through the 1:25 000 geochemical survey work in east Kunlun, the Guoluolongwa large gold deposit, Annage and Walega middle gold deposit, Langmuri copper nickel occurrence have been founded.Therefore, 1:25 000 geochemical survey methods can be applied in Aerjin, North Qaidam and other similar geochemical landscape area.