Abstract: The Sanchahebei gold polymetallic deposit is located in the middle part of East Kunlun polymetallic metallogenic belt, and the mineralization in this area was mainly occurred in the contact zone between Qingbanshisu group and Shasongwula group. This mineralization was controlled by the NWW-trending fault, which is the most direct sign for prospecting gold mineralization. The gold mineralization is related to tectonic altered rock, while the copper polymetallic mineralization is related to phyllitic slate and marble in this mining area. After carrying out 1:10000 soil survey, trenching and drilling engineering in the three Au, Sn and Mo anomaly target area (HS_乙3¹⁶、HS_乙3²⁴、HS_乙2³⁹) of 1:50000 stream sediment, we marked out four fragmentation and alteration zones (Sb1, Sb2, Sb3, Sb4) and two gold mineralization bodies (MⅠ-1, MⅢ), five polymetallic bodies (MⅠ-2, MⅡ, MⅣ, MⅤ, and MⅥ). Through using the comprehensive prospecting method of 1:200,000 stream sediment measurement, 1:50,000 stream sediment geochemical survey, 1:10,000 soil geochemical survey geological and engineering verification, the ore prospecting target area has been narrowed continuously, and a good ore prospecting effect has been achieved. Among them, the fracture alteration type Au deposit has been found in Sb1 and Sb3 fragmentation and alteration zone, the vanadium, molybdenum deposits and associated platinum group deposits that related to black rock series have been discovered in Sb2 and Sb4 fragmentation and alteration zone. If the further work will be carried out, it is expected to find a certain scale of vanadium, molybdenum deposits and associated platinum group deposits that related to black rock series, as well as fracture alteration type Au deposit. In conclusion, the Sanchahebei area has excellent metallogenic geological conditions and developed geochemical anomalies, where has found good prospecting information for silver polymetallic deposit, showing that this area has a large ore prospecting potential and is expected to achieve good ore prospecting results by carrying out further work.