Abstract: Fluorite is a strategically important nonmetallic mineral, the research on its genesis is of significant importance. This paper reviews the progress of genetic research methods in order to promote the in-depth study of the genesis of domestic fluorite deposits and make a contribution to a new round of prospecting breakthrough strategy. The distribution characteristics and genetic types of fluorite deposits worldwide and in China are summarized. Furthermore, the current status and progress of the main research methods in fluid inclusions, ore-forming fluids and material sources, and ore-forming geochronology are reviewed. The fluid inclusion assemblage and in-situ composition techniques of single fluid inclusion of fluorite are summarized, and the source of H-O-Sr-Ca-Nd isotope tracer and the fine reflection of in-situ trace rare earth elements on the mineralization process are discussed. The author proposes that the in-situ analysis technique should be employed to test the fluid inclusions and fluorite components, thereby enabling a more accurate description of the evolution process of ore-forming fluid components. The application of Lu-Hf, U-Pb, Sm-Nd, (U-Th)/He and fission track geochronology of fluorite is not only important for the accurate determination of the ore-forming age of fluorite-bearing deposits, but also necessary for the correct interpretation of deposit uplift and denudation in ore-forming exploration.