Abstract: Zhangmu, located in middle Himalayas, is an important trading port between China and Nepal and serves as the regional economic development center. Special geological and topographical characteristics and abundant precipitation provide sufficient conditions for the frequent occurrence of geological disasters, especially the landslide disasters in the region. As a large number of house buildings were built on the deposit of Zhangmu landslide, the landslide disasters seriously threaten the safety and property of the local people, and restrict the development of port economy. Previous studies on the stability of Zhangmu landslide deposit only focus on the rainstorm condition and the seismic action simplified by strength reduction method while ignoring the dynamic action process of the earthquake and the influence of human activities. In order to accurately demonstrate the stability of the landslide deposit under dynamic load, this paper calculated the dynamic safety coefficients under extreme conditions such as earthquake and vehicle vibration according to field investigations, and evaluated the ultimate bearing capacity by block based on the characteristics of geology, topography and existing landslides distribution. The results show that the deposit of ancient landslide is generally stable, but the bearing capacity of the front and back edge sections is relatively low. The modern landslide has poor stability and no further load-bearing space. Therefore, it is prohibited for the modern landslide to increase the apparent load. The conclusions of this paper provide scientific support for the systematic control of Zhangmu landslide, the layout of Zhangmu construction land and the sustainable development of the trading port.