Abstract: Ore-forming geological conditions,characteristics of geophysics, geochemistry and distribution of mineral resources in the Maiergaixi Region,Southwest Tianshan Orogeny, were analyzed on the basis of previous research results and regional geology together with prospecting practice.It indicated that the most promising minerals are copper,lead,gold and stibium in the region. The deposit types for prospecting in the region are copper deposits related with volcanics,transformed sedimentary copper and lead-zinc deposits,hydrothermal type lead-zinc deposits,stibium-gold deposits related with hydrothermal fluid and gold deposits of tectonic altered rock.The discovered deposits occurred in clastic rocks of paleozoic Upper Siliurian-Lower Devonian Wupataergan terrain and the Yuoshihan ophiolitic rock. The deposits distributed in the outer contact zone of Ludeniewa rock terrain were controlled by compressor-shear faults trending for EW and NEE-SWW.The ore-forming had close relationship with Ludeniewa rock terrain, and abnormal geophysical and geochemical exploration. Six favorable ore-prospecting areas and eight prospecting targets had been delineated. The most promising minerals,deposit types,clues for prospecting and prospecting potential were discussed and summarized. The analysis and ranking for the eight targets are expected to be referenced by field geologists.